[Biosig-etc] Biologische Signale Seminarvortrag heute

Andreas Kuhn Andreas.Kuhn at uni-hohenheim.de
Do Jul 14 10:59:44 CEST 2016

Liebe Kolleginnen und Kollegen,
liebe Freunde der Biologischen Signale Seminarreihe,

Zur Erinnerung:

ich darf Sie zum heutigen Vortrag unserer Biologische Signale Seminarreihe
in diesem Semester einladen:

"Evidence for a Non-endosomal Role of the Yeast ESCRT-III Protein Chm7  
at the Endoplasmic Reticulum"


Prof. Dr. Ralf Kölling

Institut für Lebensmittelwissenschaft und Biotechnologie
Fachgebiet Hefegenetik und Gärungstechnologie (150f)

Donnerstag, 14. Juli 2016, 17:15 Uhr
Hörsaal Ö2, Universität Hohenheim


ESCRT-III proteins are membrane remodeling factors involved in a  
multitude of cellular processes, such as endosomal protein sorting,  
HIV budding, cytokinesis, plasma membrane repair, neuron pruning,  
autophagy and resealing of the nuclear envelope during mitosis. The  
ESCRT-III system is very ancient and found in all eukaryotic organisms  
and even in archaebacteria. It was first identified in yeast by its  
role in endosomal protein sorting, still the most thoroughly studied  
and best-understood process involving ESCRT proteins. We explored the  
function of a noncanonical member of the ESCRT-III protein family, the  
Saccharomyces cerevisiae ortholog of human CHMP7. Very little was  
known about this protein until very recently. Our data indicate that  
yeast Chm7 is not involved in multivesicular body sorting in the  
endocytic pathway, but rather performs a novel function at the  
endoplasmic reticulum as part of an alternative ESCRT-III complex.

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